Health data from nearly 20,000 people who have had SARS-CoV-2 is now available to researchers across the U.S., opening new opportunities to study COVID-19 disease prevention, progression, and recovery. These records are part of the National Institutes of Health’s All of Us Research Program’s expanded dataset encompassing clinical, genomic, and participant-reported information. In addition to the COVID-19 data, the program has added more than 57,600 initial responses from its new social determinants of health (SDOH) survey to drive novel insights into how lived experiences affect health.