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Biology Department Seminar
September 14, 2020 @ 12:00 pm - 12:50 pm
Monday September 14, 2020, online from 12:00-12:50 – Join the seminar
“The Intersection of Epigenetics and the Mitochondria in Pediatric Glioma”
Assistant Professor, Department of Neurological Sciences
University of Vermont
Dr. Stafford studies how neuropsychiatric diseases arise from the abnormal regulation of gene expression in the brain (e.g., epigenetic mechanisms). His lab unifies the study of how chromatin machinery impacts transcription in the brain with behavioral models of disease. In doing so, he aims to better understand neuropsychiatric diseases from the functional level of a gene/protein to the phenotypic level of a living organism. This work requires a variety of molecular biology techniques, mechanistic biochemistry assays, genome-wide sequencing, neural cell culture systems, as well as genetic and behavioral mouse models. To keep the basic science grounded in human disease, the Stafford Lab collaborates with a host of clinician scientists. Because the general approaches of the Stafford Lab are broad, so are some of the translational questions. However, the primary disease focus of the lab is on how aberrations in chromatin machinery lead to complex phenotypes in the adult such as alcohol use disorders. A second line of research investigates select neurodevelopmental diseases such as pediatric brain tumors, epilepsy and intellectual disabilities associated with mutations in specific chromatin factors.